Organotin-induced hyperglycemia in the crab, Oziotelphusa senex senex Fabricius.

On the mode of action of methionine enkephalin, FK 33-824 and naloxone in regulating the hemolymph glucose level in the fresh water field crab Oziotelphusa senex senex.

The possible involvement of opioid system in the regulation of hemolymph glucose level in the fresh water crab Oziotelphusa senex senex Fabricius, was investigated. Opioid agonist and antagonist was also used in addition to methionine-enkephalin itself. Injection of the opioid, methionine-enkephalin and FK 33-824 significantly elevated hemolymph glucose level. In contrast, injection of naloxone...

Role of vertebrate steroids in the regulation of testicular development in the fresh water crab, Oziotelphusa senex senex

Background: Crustacean reproduction is under the control of various peptide and steroid hormones including vertebrate steroids. In the present study, we examined the role of vertebrate steroids, progesterone and 17βestradiol in the regulation of testicular development in the crab Oziotelphusa senex senex. Methods: The crabs were divided into eight groups, first group served as initial control a...

Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.

Cellular senescence is a mechanism to inhibit the growth of mammalian cells after oncogenic activation, or in response to damage or stress. We describe here the identification of a novel gene, SENEX, that regulates stress induced premature senescence pathways in endothelial cells (ECs) involving p16(INK4a) and retinoblastoma protein activation. Endogenous levels of SENEX remain unchanged during...

A Novel Cellular Senescence Gene, SENEX, Is Involved in Peripheral Regulatory T Cells Accumulation in Aged Urinary Bladder Cancer

Regulatory T cells (Tregs) play an essential role in sustaining self-tolerance and immune homeostasis. Despite many studies on the correlation between Tregs accumulation and age, or malignancies, the related mechanism hasn't been well explored. To find out the mechanism of Tregs accumulation in aged urinary bladder cancer, we examined the novel cellular senesence gene SENEX and relevant apoptos...

Research for improved quality of life of older persons Recommendations based on expert group discussions carried out within the Nutri-Senex project - a co-ordination action funded by the European Commission